This project will classify the pipeline and tank systems based on criteria such as production floor layout, process lines, and upstream/downstream stages. The control system employs the SIEMENS PCS7 platform with Batch functionality. The system architecture is built on a 410-5H CPU, with communication between the CPU and I/O modules realized via a Profinet ring network. The overall design adopts a server-client model and is equipped with a corresponding number of HMI industrial computers. All electronic and electrical equipment must comply with explosion-proof requirements applicable to their respective zones.

The Human-Machine Interface (HMI) screen layouts and logic control programs will be developed and configured strictly in accordance with user specifications, ultimately forming independent functional modules for each program.

The PCS7 system achieves comprehensive control over both upstream synthesis and downstream purification processes, including preparation of reagents such as deprotection agents, activators, sulfurizing agents, iodine solutions, and post-treatment solutions; feeding, draining, and cleaning of buffer lines containing DMF, ammonia solution, ethanol, dichloroacetic acid, and other media; and assisting the synthesizer in completing the key steps of oligonucleotide synthesis, namely deprotection, coupling, capping, oxidation, and cleavage. Downstream system control covers feeding and discharging of vessels such as concentrated alkali tanks, salt solution tanks, and phosphate buffer tanks, and supports the neutralization, annealing, and ultrafiltration purification of oligonucleotides.