This project is based on the DeltaV automation platform, seamlessly integrating ultrafiltration and depth filtration control functions into the existing server architecture. Below the controller level, the open industrial Ethernet protocol EtherNet/IP is adopted to enable efficient communication, stably connecting Siemens ET200 series distributed I/O racks and related functional cards. The platform integrates key third-party process detection instruments (such as pH, conductivity, pressure, temperature, turbidity sensors, etc.) to establish an automated control platform that complies with data integrity requirements. The configuration meets cGMP regulatory requirements and provides a comprehensive depth filtration and ultrafiltration system solution. The system is deployed in production environments with different cleanliness levels: depth filtration is performed in a Grade D clean area to effectively remove cell debris and particulate impurities from samples; ultrafiltration concentration and diafiltration operations are carried out in a Grade C clean area to increase the concentration of target products and perform buffer exchange, respectively. The depth filtration system integrates feed pumps, sample flow paths, permeate flow paths, CIP cleaning flow paths, and drainage flow paths, with all flow path switching automatically controlled by pneumatic diaphragm valves. The ultrafiltration system offers more comprehensive functionality: in addition to all the above flow paths, it specifically integrates membrane integrity test gas flow paths and permeate recirculation flow paths. Similarly, fully automated flow path switching and process control are achieved through highly reliable pneumatic diaphragm valves.